{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:39:23Z","timestamp":1785159563555,"version":"3.55.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> The prognosis of patients with advanced sarcoma remains poor. Whether high-dose chemotherapy with stem cell support improves the long-term outcome for these patients or not is controversial. <i>Methods:<\/i> We present a large institutional experience of sarcoma patients treated with this therapy option. Thirty-eight patients with bone (n = 17) and soft tissue sarcomas (n = 21) were included. Apart from haematological complications, no WHO grade III\u2013IV complications were observed. One patient died due to cardiac arrest after transplantation. <i>Results:<\/i> Following chemotherapy and\/or surgery, but prior to high-dose chemotherapy, diagnoses were made of: no evidence of disease (NED; n = 12), partial remission (n = 17), stable disease (n = 3) and progressive disease (PD; n = 6). Six patients died within 8 months due to PD, in 18 patients disease recurred and led to death and 13 patients are alive with\/without disease. Median progression-free survival was 19.1 months (range: 0\u2013121) for all patients, and 48.8 months (range: 3\u2013121) for 12 patients with NED. <i>Conclusion:<\/i> A subgroup of patients with NED before high-dose chemotherapy gained survival benefit. Therefore, we emphasize the value of high-dose chemotherapy as a treatment option for younger patients with a good performance status in partial or complete remission.<\/jats:p>","DOI":"10.1159\/000120629","type":"journal-article","created":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T19:43:08Z","timestamp":1205350988000},"page":"58-64","source":"Crossref","is-referenced-by-count":11,"title":["Large Institutional Experience with Dose-Intensive Chemotherapy and Stem Cell Support in the Management of Sarcoma Patients"],"prefix":"10.1159","volume":"73","author":[{"given":"Bernd","family":"Kasper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunhild","family":"Mechtersheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlinde","family":"Egerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,3,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F1040-8428%2894%2900146-K"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819940515%2973%3A10%3C2506%3A%3AAID-CNCR2820731009%3E3.0.CO%3B2-S"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2897%2900102-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2896%2900297-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819971001%2980%3A7%3C1221%3A%3AAID-CNCR4%3E3.0.CO%3B2-N"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2897%2989006-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2002.08.081"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bmt.1703023"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00001622-200403000-00006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-2265.2004.00185.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS1040-8428%2801%2900153-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS1040-8428%2801%2900150-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2897%2900247-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bmt.1704520"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000085704"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2897%2900101-9"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/120629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/120629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:54:27Z","timestamp":1745459667000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000120629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":16,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000120629","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}