{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:00:21Z","timestamp":1777946421166,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T00:00:00Z","timestamp":1204848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T00:00:00Z","timestamp":1204848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Neurosurg"],"abstract":"<jats:p>The \u2018cerebrospinal fluid (CSF) accumulator\u2019 plays an important physiological role in the healthy central nervous system as both a shock absorber and regulator of drainage. In the presence of hydrocephalus, this function is compromised by resistance to the flow of CSF. It is further compromised by the placement of a standard shunt which allows only for one-way directional diversion of the fluid. Complications associated with shunt dependency may be a direct consequence of both the condition, and a failure of existing systems to restore the normal accumulator function. This article reviews the pathophysiology of the \u2018CSF accumulator\u2019 as it relates to hydrocephalus and its management, and proposes a biomimetic shunt designed to restore the \u2018CSF accumulator\u2019 toward normal. It is hoped that such a device will support normalization of intracranial pressure and restore an appropriate level of CSF volume in the shunted patient.<\/jats:p>","DOI":"10.1159\/000121198","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T05:47:34Z","timestamp":1204868854000},"page":"236-246","source":"Crossref","is-referenced-by-count":2,"title":["The CSF Accumulator: Its Role in the Central Nervous System and Implications for Advancing Hydrocephalus Shunt Technology"],"prefix":"10.1159","author":[{"given":"Gary","family":"Magram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Liakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,7]]},"container-title":["Pediatric Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000121198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T17:19:51Z","timestamp":1777742391000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000121198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000121198","archive":["Portico"],"relation":{},"ISSN":["1016-2291","1423-0305"],"issn-type":[{"value":"1016-2291","type":"print"},{"value":"1423-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,7]]}}}