{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:14:29Z","timestamp":1760501669461,"version":"3.40.4"},"reference-count":35,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Dyspepsia is defined as a chronic or recurrent pain centered in the upper abdomen. Dyspeptic symptoms have a high prevalence in the population and represent a common reason for patients to see a primary care physician. Therefore, dyspepsia displays a major health care burden and produces high socioeconomic costs. The etiology of dyspeptic symptoms is various and complex and has opened a wide spectrum of putative mechanisms. In a subset of patients dyspeptic symptoms are likely to originate from &lt;i&gt;Helicobacter pylori &lt;\/i&gt;infection. Population-based studies have demonstrated that &lt;i&gt;H. pylori&lt;\/i&gt; is detected more frequently in dyspeptic patients compared to controls. &lt;i&gt;H. pylori&lt;\/i&gt; eradication therapy gives modest but significant benefit in non-ulcer dyspepsia and leads to long-term symptom improvement. It also reduces the risk of developing peptic ulcer disease and other &lt;i&gt;H. pylori&lt;\/i&gt;-related gastric pathologies (i.e. atrophic gastritis, gastric cancer). The main therapeutic strategy for managing dyspepsia in patients under the age of 45 years is \u2018test and treat\u2019. &lt;i&gt;H. pylori&lt;\/i&gt; eradication is recommended in patients with dyspepsia and no other gastroduodenal abnormalities than &lt;i&gt;H. pylori&lt;\/i&gt; induced gastritis. In patients presenting with alarm features a prompt upper endoscopy should be performed to exclude peptic ulcer disease, esophageal and gastric malignancies or other more rare upper gastrointestinal diseases.<\/jats:p>","DOI":"10.1159\/000121348","type":"journal-article","created":{"date-parts":[[2008,5,6]],"date-time":"2008-05-06T14:30:07Z","timestamp":1210084207000},"page":"210-214","source":"Crossref","is-referenced-by-count":14,"title":["Dyspepsia and &lt;i&gt;Helicobacter pylori&lt;\/i&gt;"],"prefix":"10.1159","volume":"26","author":[{"given":"Michael","family":"Selgrad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Kandulski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Malfertheiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,5,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2004.01897.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200201000-00010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2165%2F00019053-200220050-00006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.11.059"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2005.00225.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.39014.468900.BE"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.36.4.534"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053%2FS1542-3565%2803%2900184-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1010612509593"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1018803129779"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.1996.v110.pm8612991"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2898%2970012-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2001.03683.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cgh.2007.05.015"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-199903000-00003"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.324.7344.1012"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080%2F00365520410003452"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2006.101634"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.163.10.1165"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0691.2003.00707.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.48.3.287"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2004.043570"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F01.meg.0000108366.19243.3a"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2902553-8"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.163.13.1606"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.324.7344.999"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.45.2.186"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinthera.2005.10.011"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02063953"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2002.33019"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2006.00673.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2005.41688.x"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199812243392601"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199812243392602"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.52.1.40"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/121348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/121348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:02:39Z","timestamp":1745460159000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000121348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000121348","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"type":"print","value":"0257-2753"},{"type":"electronic","value":"1421-9875"}],"subject":[],"published":{"date-parts":[[2008]]}}}