{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:19:10Z","timestamp":1777918750245,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T00:00:00Z","timestamp":1205971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T00:00:00Z","timestamp":1205971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>The effects of selective degeneration of brainserotoninergic nerve terminals by 5,6-dihydroxytryptamine (5,6-DHT) injected intraventricularly in prepuberal male rats were studied in 2 experiments. In both experiments, male Sprague-Dawley rats were injected in a lateral ventricle of the brain at 21 and 23 days of age with either 5,6-DHT or vehicle, and autopsied 1,2 and 4 weeks after the 1st injection. Controls were either pair-fed or fed ad lib. In the first experiment the effects of 5,6-DHT on body and organ growth and pituitary levels of radioimmunoassayable growth hormone (GH) were studied. In the second experiment the effects of 5,6-DHT on plasma and pituitary levels of radioimmunoassayable follicle-stimulating hormone (FSH) were studied. Histological examinations of the testes obtained at 4 weeks were performed. Experimental animals on the whole ate 41.8 % less food than controls fed ad lib. The analysis of variance showed that experimental animals, when compared with pair-fed controls, had significantly lower brain 5-HT levels (as measured by spectrophotofluoro-metry) at 1 and 2 weeks, significantly lower body weights at 1 week, and significantly smaller tails at 1 and 2 weeks after the first injection. Brain weights of experimental rats were significantly lower than those of controls fed ad lib. at 2 and 4 weeks; those of pair-fed animals, although lower at 2 weeks, were not significantly different from brain weights of controls fed ad lib. at 4 weeks. At 4 weeks, testes weights (corrected for body weights) were significantly lower in experimental rats than in controls fed ad lib. At 2 weeks, both the experimental and the pair-fed group had pituitary GH levels (corrected for body weights) lower than those of the group fed ad lib. Plasma FSH levels were undetectable at 1 week both in experimental and pair-fed animals. Pituitary FSH concentration was significantly reduced at 2 weeks and significantly increased at 4 weeks in the experimental rats when compared with the controls fed ad lib. Histological examination of the testes showed that controls fed ad lib. and pair-fed had reached full spermatogenesis at 4 weeks after the 1st injection (51 days of age); spermatogenesis of experimental animals was usually blocked at the stage of pachytene spermatocytes. In conclusion, depletion of brain 5-HT inhibited body and brain growth and sexual maturation partly through the ensuing anorexia and malnutrition, but possibly also through a specific decrease in synthesis and\/or secretion of GH and FSH.<\/jats:p>","DOI":"10.1159\/000122254","type":"journal-article","created":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T03:07:12Z","timestamp":1206414432000},"page":"139-150","source":"Crossref","is-referenced-by-count":8,"title":["Endocrine Effects of Brain Serotonin Depletion by 5,6-Dihydroxytryptamine in Prepuberal Male Rats"],"prefix":"10.1159","author":[{"given":"R.","family":"Collu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-C.","family":"J\u00e9quier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Letarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Leboeuf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Ducharme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,20]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/122254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000122254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:45:17Z","timestamp":1777661117000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000122254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000122254","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,20]]}}}