{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:22:40Z","timestamp":1777918960845,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T00:00:00Z","timestamp":1206403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T00:00:00Z","timestamp":1206403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>Hemiovariectomized rats were randomly assigned to 1 of 5 groups: controls, 6-hydroxydopamine (6-HD)-treated, abdominal vagotomy, 6-HD-treated plus abdominal vagotomy and pelvic parasympathectomy. 15 days later all animals were sacrificed and the amount of compensatory ovarian hypertrophy (COH) was calculated. Vagotomy and vagotomy plus 6-HD treatment interrupted estrous cycles and significantly decreased COH. Vagotomized rats with both ovaries intact had disrupted estrous cycles but ovarian weights were not affected. In a subsequent study, rats in estrus were sham-operated, unilaterally ovariectomized (ULO), vagotomized, or vagotomized + ULO, and serum levels of LH and FSH were determined at 5 and 24 h. ULO caused a significant (p &lt; 0.05) increase in LH and FSH at 5 h. Vagotomy significantly (p &lt; 0.05) depressed LH and FSH levels in hemiovariectomized animals at 5 h. By 24 h LH was significantly higher in ULO than in either sham-operated (p &lt; 0.05) or vagotomy (p &lt; 0.01) groups. Also, vagotomy significantly (p &lt; 0.01) depressed FSH levels at 24 h. These results suggest a functional role for the vagus nerve in normal cyclic activity, COH, and gonadotrophin (Gn) secretion.<\/jats:p>","DOI":"10.1159\/000122685","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T11:20:14Z","timestamp":1206530414000},"page":"368-378","source":"Crossref","is-referenced-by-count":44,"title":["The Effect of Denervation on Compensatory Ovarian Hypertrophy"],"prefix":"10.1159","author":[{"given":"H.W.","family":"Burden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.E.","family":"Lawrence jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,25]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000122685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:51:00Z","timestamp":1777661460000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000122685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000122685","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,25]]}}}