{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:23:35Z","timestamp":1777919015723,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the summer season. The intraperitoneal (i.p.) 5-hydroxytryptophan (5-HTP) administration blocked the compensatory increase in plasma T that followed its drop induced by hemicastration. At the same time, under similar experimental conditions, a preliminary injection of p-chlorophenyl-alanine (PCPA) was accompanied by a more marked rise of plasma T than in control unilaterally castrated rats. After the injection of serotonin (5-HT) into the lateral ventricle of the brain there was no effect on the blood T content in rats with intact gonads. However, 5-HT injection to hemicastrated animals under similar conditions completely prevented the compensatory increase of T level in blood after its fall caused by the operation. On the other hand, double intraventricular injection of methysergide was followed by a more marked rise of blood T content as compared with the control hemicastrated rats. The conclusion is drawn that brain serotoninergic neurons are involved in feedback mechanisms related to the control of hypothalamic-pituitary-testicular complex.<\/jats:p>","DOI":"10.1159\/000122791","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T11:20:14Z","timestamp":1206530414000},"page":"359-366","source":"Crossref","is-referenced-by-count":8,"title":["Role of Serotonin in Feedback Control of Hypothalamic-Pituitary-Testicular Complex in Male Rats"],"prefix":"10.1159","author":[{"given":"E.V.","family":"Naumenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.T.","family":"Shishkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,26]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/122791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000122791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:52:27Z","timestamp":1777661547000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000122791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000122791","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,26]]}}}