{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:25:25Z","timestamp":1777919125471,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>The existence of typical muscarinic receptors in membranes of sheep anterior pituitary was detected by binding of [3H]quinuclidinyl benzilate ([3H]QNB), a potent and specific muscarinic antagonist. [3H]QNB binding sites in anterior pituitary had an equilibrium dissociation constant of about 20\u201340 pM, a rate constant for association at 37 C of about 2 \u00d7 108M\u20131 min\u20131, a rate constant for dissociation at 37 C of about 4 \u00d7 10\u20133 min-1 and the expected specificities for a variety of choiinergic and other drugs. The concentration of [3H]QNB binding sites in anterior pituitary, about 4\u20136 pmol\/g tissue, was at least twice that in posterior pituitary, but less than a quarter that in the hypothalamus. Since there is no established choiinergic or other innervation of the anterior pituitary, the presence there of typical muscarinic receptors, if we assume that they are functional, suggests that acetylcholine reaches the tissue through the hypophyseal portal circulation, and that it may thus have a role in the regulation of pituitary function.<\/jats:p>","DOI":"10.1159\/000123026","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T11:20:14Z","timestamp":1206530414000},"page":"344-349","source":"Crossref","is-referenced-by-count":34,"title":["Muscarinic Receptor Binding in Sheep Anterior Pituitary"],"prefix":"10.1159","author":[{"given":"David R.","family":"Burt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,26]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000123026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:55:36Z","timestamp":1777661736000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000123026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000123026","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,26]]}}}