{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:27:45Z","timestamp":1777919265924,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>The effects of intraventricular (i.v.t.) morphine sulfate (MS) and \u03b2-endorphin (\u03b2-EP) on pituitary-adrenal activity and the release of pituitary \u03b2-EP were studied in rats. Pituitary-adrenal activity was monitored by measuring plasma corticosterone (CS) levels. 45 min after i.v.t. injection, both MS and \u03b2-EP caused dose-related increases in plasma CS, with \u03b2-EP being approximately ten times more potent on a molar basis. MS injected i.v.t. at 0.3, 1.0, 3.0 and 10.0 \u03bcg did not cause a significant reduction in pituitary immunoreactive (i.r.) \u03b2-EP, but did cause an increase in plasma i.r. \u03b2-EP at 3 \u03bcg of MS. \u03b2-EP injected i.v.t. at 1.5 \u03bcg caused a reduction of pituitary i.r. \u03b2-EP. Since i.v.t.-injected \u03b2-EP may have contributed to the measured plasma i.r. \u03b2-EP, a nonimmunoreactive analog (Des-Asn20-\u03b2&lt;sub&gt;c&lt;\/sub&gt;-EP) was used to assess the change in plasma i.r. \u03b2-EP. 5 \u03bcg of Des-Asn20-\u03b2&lt;sub&gt;c&lt;\/sub&gt;-EP injected i.v.t. caused increases in plasma i.r. \u03b2-EP and CS, as well as a 40% reduction in pituitary i.r. \u03b2-EP. The concomitant intraperitoneal (i.p.) injection of naloxone HC1 (10 mg\/kg) significantly blocked the increase in plasma CS induced by 5 \u03bcg of \u03b2-EP. When naloxone HC1, 10 mg\/kg was injected alone, a significant increase in plasma CS was found. The results indicate that i.v.t. \u03b2-EP is more potent than MS in causing the release of pituitary ACTH and \u03b2-EP. These findings are consistent with a role for brain endorphins in the regulation of CRF release.<\/jats:p>","DOI":"10.1159\/000123224","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T11:20:14Z","timestamp":1206530414000},"page":"170-175","source":"Crossref","is-referenced-by-count":48,"title":["Effect of Intraventricular \u03b2-Endorphin and Morphine on Hypothalamic-Pituitary-Adrenal Activity and the Release of Pituitary \u03b2-Endorphin"],"prefix":"10.1159","author":[{"given":"John L.","family":"Haracz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.I.H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Fu","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,26]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/123224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000123224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:58:22Z","timestamp":1777661902000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000123224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000123224","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,26]]}}}