{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:36:22Z","timestamp":1777919782734,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>It has now been established that there is an interaction between the cardiovascular control systems and opiate substances. To assess the role of endogenous opiates in the long-term control of blood pressure, the opiate antagonist naloxone (0.5 mg\/kg\/24 h) was infused intravenously for 7 days. Chronic blockade of endogenous opiates resulted in an elevation in arterial blood pressure which averaged 11% and was sustained throughout the infusion period. This was accompanied by a significant decrease in plasma renin activity averaging -59%. These data provide support for a tonic role of opioids in the long-term control of the cardiovascular system which may involve baroreceptor function.<\/jats:p>","DOI":"10.1159\/000124537","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T11:56:21Z","timestamp":1207137381000},"page":"110-114","source":"Crossref","is-referenced-by-count":7,"title":["Cardiovascular Effects of Chronic Naloxone Infusion in Normal Dogs"],"prefix":"10.1159","author":[{"given":"Julianna E.","family":"Szilagyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos M.","family":"Ferrario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,1]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/124537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000124537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:11:49Z","timestamp":1777662709000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000124537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000124537","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,1]]}}}