{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:20:57Z","timestamp":1792113657654,"version":"4.4.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>These experiments were designed to characterize the nature and extent of diabetes insipidus present in a new model of genetic vasopressin (VP) deficiency, the Roman high avoidance rat homozygous for diabetes insipidus (RHA: di\/di strain). The new strain was developed from an initial cross between Long-Evans derived Brattleboro (LE: di\/di) rats and normal Roman high avoidance (RHA: +\/+ ) rats, and has been bred to be congenic with the parent RHA: +\/+ strain. RHA: di\/di rats exhibited polydipsia, excreted dilute urine, and exhibited elevated plasma osmolality. RHA: di\/di rats showed a similar urinary response to dehydration as LE: di\/di rats. VP was undetectable by radioimmunoassay in the serum, brain, and neurohypophysis of RHA: di\/di rats. VP-neurophysin containing cells were not observed in the brains of RHA: di\/di rats upon immunocytochemical analysis. Thus, the new RHA: di\/di strain exhibits essentially the same profile of diabetes insipidus as the LE: di\/di rat. The congenic relationship between RHA: di\/di and RHA: +\/+ rats makes the RHA: di\/di rat a useful model under circumstances where genetic variables unrelated to VP deficiency may confound the interpretation of data.<\/jats:p>","DOI":"10.1159\/000124549","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T11:56:21Z","timestamp":1207137381000},"page":"340-347","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of a New Rodent Model of Diabetes insipidus: The Roman High Avoidance Rat Homozygous for Diabetes insipidus"],"prefix":"10.1159","author":[{"given":"James P.","family":"Herman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia D.","family":"Sladek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl T.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don M.","family":"Gash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,4,1]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/124549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000124549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:11:49Z","timestamp":1777662709000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000124549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000124549","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,1]]}}}