{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:39:29Z","timestamp":1777919969783,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T00:00:00Z","timestamp":1207094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T00:00:00Z","timestamp":1207094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"Estradiol (E<sub>2<\/sub>) produces many-fold increases in the dopamine (DA) content of the anterior pituitary and also plays a role in the age-related increase in pituitary DA in female C57BL\/6J mice. These studies address the following questions: (1) What are the time and dose characteristics of the E<sub>2<\/sub>-induced increase in pituitary DA and can other gonadal steroids \u2013 such as progesterone (P) and 5\u03b1-dihydrotestosterone \u2013 also influence pituitary DA? (2) Is the age-related increase in pituitary DA due entirely to an increase in the E<sub>2<\/sub>:P ratio seen in aging female mice, or can extra-ovarian factors also play a role? (3) Is the E2-induced (and therefore possibly the age-related) increase in pituitary DA secondary to an E<sub>2<\/sub>-induced increase in serum prolactin? In ovariectomized (OVX) mice, E2 implants increased pituitary DA in a time- and dose-dependent fashion. P implants administered to OVX mice simultaneously with E<sub>2<\/sub> antagonized the E<sub>2<\/sub>-induced increase in pituitary DA. Daily injections of 5\u03b1-dihydrotestosterone given in conjunction with E<sub>2<\/sub> implants had no effect on basal or E<sub>2<\/sub>-increased pituitary DA in OVX mice. Thus, E<sub>2<\/sub> is the only gonadal steroid examined which increases anterior pituitary DA. In intact aging mice, P attenuates the age-related increase in pituitary DA, supporting the hypothesis that the increased ratio of E<sub>2<\/sub>:P secreted by the ovaries of aging female mice is responsible for the age-related increase in pituitary DA. However, at advanced ages, intact male mice also showed modest increases in anterior pituitary DA. Therefore, extra-ovarian age changes, perhaps age changes intrinsic to the pituitary, also play a minor role in the age-related increase in pituitary DA. E<sub>2<\/sub> increases the secretion of prolactin, which can then feed back to increase secretion of DA from the tuberoinfundibular dopaminergic neurons, a source of pituitary DA. To determine if the E<sub>2<\/sub>-induced increase in pituitary DA was secondary to an E<sub>2<\/sub>-induced increase in serum prolactin, OVX mice were given pituitary grafts to increase serum prolactin independently of E<sub>2<\/sub> treatment. The E<sub>2<\/sub>-induced increase of pituitary DA is not mediated, but can be enhanced by prolactinemia.<\/jats:p>","DOI":"10.1159\/000124869","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T11:56:21Z","timestamp":1207137381000},"page":"481-487","source":"Crossref","is-referenced-by-count":4,"title":["Hormonal Influences on the Estradiol-Induced and Age-Related Increases of Pituitary Dopamine in C57BL\/6J Mice"],"prefix":"10.1159","author":[{"given":"Nancy","family":"Telford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yagya N.","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caleb E.","family":"Finch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,2]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/124869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000124869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:16:43Z","timestamp":1777663003000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000124869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000124869","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,2]]}}}