{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:42:51Z","timestamp":1777920171997,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T00:00:00Z","timestamp":1207094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T00:00:00Z","timestamp":1207094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>Accurel polypropylene mini-devices, loaded with arginine vasopressin (AVP) and implanted in the lateral cerebral ventricle were used to centrally treat heterozygous (HE) and homozygous (HO) Brattleboro (BB) rats. After 1 week of treatment, the concentration of AVP receptors in the HO-BB rat septum decreased from 19.4 \u00b1 2.6 to 12.4 \u00b1 1.1 fmol\/mg protein, but remained unchanged in the HE-BB rat (10.7 \u00b1 0.8 and 7.0 \u00b1 1.1 fmol\/mg protein). In the HO-BB rat the [\u0397]-AVP equilibrium dissociation constant (K&lt;sub&gt;D&lt;\/sub&gt;) of the septal AVP receptor decreased following AVP treatment (from 4.17 \u00b1 0.7 to 1.97 \u00b1 0.3 nM) compared to that of control animals. This decrease in receptor number following AVP treatment was accompanied by a decrease in the postreceptor response to AVP as measured by the AVP-stimulation of [3H]-inositol-1-phosphate (IP&lt;sub&gt;1&lt;\/sub&gt;) accumulation (22.0 \u00b1 6.1%) when compared to untreated animals (54.3 \u00b1 8.3%). This apparent AVP-induced down-regulation was not due to occupancy of the binding sites by AVP since preincubation of the tissue at 37 \u00b0C for 60 min (which was able to cause near-complete dissociation of the hormone-receptor complex) did not result in an increased number of binding sites upon reexposure to [3H]-AVP. This study thus provides evidence for the homologous down-regulation and desensitization in terms of [3H]-IP&lt;sub&gt;1&lt;\/sub&gt; accumulation (phosphoinositide hydrolysis) of AVP receptors in the septum of the BB rat.<\/jats:p>","DOI":"10.1159\/000125236","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T11:56:21Z","timestamp":1207137381000},"page":"292-298","source":"Crossref","is-referenced-by-count":12,"title":["Regulation of Vasopressin Receptors and Phosphoinositide Hydrolysis in the Septum of Heterozygous and Homozygous Brattleboro Rats"],"prefix":"10.1159","author":[{"given":"Linda M.","family":"Shewey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard J.","family":"Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Szot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Dorsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,2]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/125236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000125236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:22:31Z","timestamp":1777663351000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000125236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000125236","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,2]]}}}