{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:44:08Z","timestamp":1777920248624,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T00:00:00Z","timestamp":1207180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T00:00:00Z","timestamp":1207180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>\u03b2-Endorphin and ACTH are secreted concomitantly in baseline conditions and in response to physiological and pharmacological stimuli. However, few and contradictory data are available on their feedback inhibition mechanisms. To investigate this aspect, the effects of exogenous ACTH&lt;sub&gt;1\u201324&lt;\/sub&gt; and glucocorticoids on endogenous ACTH&lt;sub&gt;1\u201339&lt;\/sub&gt; and \u03b2-endorphin were tested in 18 patients with Addison\u2019s disease. Two main experimental protocols were employed: (1) 7 patients were given ACTH&lt;sub&gt;1\u201324&lt;\/sub&gt; 50 \u00b5g as an intravenous bolus followed by a 50-\u00b5g infusion in 90 min. Blood samples for \u03b2-endorphin, ACTH and cortisol were obtained at 0, 15, 30, 45, 60, 90, 120 min. Six other patients were given oCRH 100 \u00b5g i.v. plus ACTH&lt;sub&gt;1\u201324&lt;\/sub&gt;, as described above. (2) In 5 other patients, hydrocortisone 37.5 mg was administered i.v. in 90 min. Blood samples for \u03b2-endorphin, ACTH and cortisol were drawn at 0, 15, 30, 45, 60, 90, 120 min. One week later, the same patients were given oCRH 100 \u00b5g i.v. and hydrocortisone 37.5 mg, as described above. ACTH&lt;sub&gt;1\u201324&lt;\/sub&gt; administration caused a significant (p &lt; 0.01) decrease in endogenous ACTH but not in \u03b2-endorphin. oCRH injection significantly stimulated both ACTH and \u03b2-endorphin. The response of both ACTH and \u03b2-endorphin was inhibited by exogenous ACTH&lt;sub&gt;1\u201324&lt;\/sub&gt;. There was a potent inhibition by hydrocortisone on both basal and stimulated \u03b2-endorphin, confirming that the feedback mechanism of glucocorticoids concomitantly inhibits ACTH and \u03b2-endorphin. On the other hand, only CRH-stimulated but not basal secretion of \u03b2-endorphin seems affected by ACTH ultrashort feedback, suggesting an intrapituitary regulation.<\/jats:p>","DOI":"10.1159\/000125391","type":"journal-article","created":{"date-parts":[[2008,4,4]],"date-time":"2008-04-04T09:10:05Z","timestamp":1207300205000},"page":"561-564","source":"Crossref","is-referenced-by-count":9,"title":["Inhibition of Pituitary \u03b2-Endorphin by ACTH and Glucocorticoids"],"prefix":"10.1159","author":[{"given":"Marco","family":"Boscaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostino","family":"Paoletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Giacomazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Fallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Sonino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,3]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/125391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000125391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:24:56Z","timestamp":1777663496000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000125391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000125391","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,3]]}}}