{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:44:28Z","timestamp":1777920268531,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T00:00:00Z","timestamp":1207180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T00:00:00Z","timestamp":1207180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>The coadministration of growth hormone (GH) secretagogues can provide insight into the neuroregulation of GH secretion. The GH response to L-dopa (125, 250 and 500 mg orally for body weights &lt; 15 kg, between 15 and 30 kg and &gt; 30 kg, respectively), arginine (Arg; 0.5 g\/kg infused intravenously over 30 min) and galanin (GAL; 15 \u00b5g\/kg infused intravenously over 60 min) when administered alone or combined with Pyridostigmine (PD; 60 mg orally), a cholinergic agonist that likely acts via inhibition of endogenous somatostatin secretion, was studied in children with familial short stature. The GH-releasing effect of PD was also evaluated. In 8 children, PD and L-dopa when administered alone induced an equivalent GH rise (area under the response curve, mean \u00b1 SEM: 241.4 \u00b1 31.1 vs. 202.9 \u00b1 38.6 \u00b5g\/l\/h) while their coadministration had an additive effect (435.4 \u00b1 41.4 \u00b5g\/l\/h; p &lt; 0.02 vs. PD and L-dopa alone). On the contrary, in other 8 children, PD and Arg induced similar GH increases either when administered alone (394.2 \u00b1 68.5 vs. 405.8 \u00b1 103.9 \u00b5g\/l\/h) or in combination (535.8 \u00b1 97.3 \u00b5g\/l\/h). GH increases almost superimposable were also observed when PD and GAL were administered alone (405.2 \u00b1 72.3 vs. 412.6 \u00b1 94.1 \u00b5g\/l\/h) or in combination (537.9 \u00b1 139.0 \u00b5g\/l\/h) in other 7 children. These data show that the enhancement of the cholinergic activity by PD increases the L-dopa-induced GH release but fails to modify both Arg- and GAL-induced GH release in short children. They may be taken to indicate that a common mechanism, i.e. suppression of endogenous somatostatin secretion, underlies the GH-releasing effect of PD, Arg and GAL, while an extra-somatostatinergic mechanism mediates the effect of L-dopa.<\/jats:p>","DOI":"10.1159\/000125536","type":"journal-article","created":{"date-parts":[[2008,4,4]],"date-time":"2008-04-04T09:10:05Z","timestamp":1207300205000},"page":"42-45","source":"Crossref","is-referenced-by-count":7,"title":["Pyridostigmine Potentiates L-Dopa- but not Arginine- and Galanin-Induced Growth Hormone Secretion in Children"],"prefix":"10.1159","author":[{"given":"Ezio","family":"Ghigo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaele","family":"Bellone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliseo","family":"Imperiale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Arvat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Mazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Rosa","family":"Valetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Mario","family":"Boffano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Cappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Loche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"de Sanctis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio E.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Camanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,3]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/125536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000125536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:25:34Z","timestamp":1777663534000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000125536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000125536","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,3]]}}}