{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:56:16Z","timestamp":1745470576256,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a complex multifactorial disorder involving a number of genetic and environmental factors. Cystatin C (CST3), which belongs to the type II cystatin gene family, is a potent inhibitor of lysosomal proteinases. Immunohistochemical studies have demonstrated the colocalization of the b-amyloid (A-beta) and cystatin C peptides within arteriolar walls in the AD brain. The G73A polymorphism of the &lt;i&gt;CST3 &lt;\/i&gt;genemay be associated with AD development&lt;i&gt;.&lt;\/i&gt; To investigate a possible association between the &lt;i&gt;CST3 &lt;\/i&gt;G73A polymorphism and late-onset AD (LOAD) in Mainland Chinese, we examined 281 LOAD patients and 376 healthy controls. All subjects were genotyped for &lt;i&gt;CST3&lt;\/i&gt; and apolipoprotein E &lt;i&gt;(APOE)&lt;\/i&gt;. There were no significant differences in the &lt;i&gt;CST3&lt;\/i&gt; genotype or allele frequencies between the cases and the controls. Likewise, with the stratification of the &lt;i&gt;APOE&lt;\/i&gt; &amp;#917;&lt;i&gt;4&lt;\/i&gt; status, no statistical difference was observed between the cases and the controls. Our findings suggest that this polymorphism may not represent an additional genetic risk factor for LOAD in Mainland Chinese.<\/jats:p>","DOI":"10.1159\/000125670","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T11:22:29Z","timestamp":1207912949000},"page":"461-464","source":"Crossref","is-referenced-by-count":13,"title":["Lack of an Association between Alzheimer\u2019s Disease and the Cystatin C &lt;i&gt;(CST3)&lt;\/i&gt; Gene G73A Polymorphism in Mainland Chinese"],"prefix":"10.1159","volume":"25","author":[{"given":"Binbin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-chen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dantao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00019052-200108000-00002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10048-004-0174-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109%2F00365519509110259"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2005.09.006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2801%2902307-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000100021"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/125670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/125670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:03:43Z","timestamp":1745460223000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000125670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":7,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000125670","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2008]]}}}