{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:51:13Z","timestamp":1777920673661,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T00:00:00Z","timestamp":1207612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T00:00:00Z","timestamp":1207612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>We studied the effects of the histamine H&lt;sub&gt;1&lt;\/sub&gt; receptor antagonists diphenhydramine and pyrilamine, the H&lt;sub&gt;2&lt;\/sub&gt; receptor antagonist ranitidine and the muscarinic receptor antagonist atropine injected into the third cerebral ventricle on prostaglandin F&lt;sub&gt;2&lt;\/sub&gt;\u03b1 (PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1)-induced hyperglycemia in anesthetized fed rats. The concomitant injection of diphenhydramine (1 \u00d7 10\u20138, 5 \u00d7 10\u20138 mol) with 50 \u00b5g PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1 significantly suppressed the increase in hepatic plasma glucose concentrations induced by PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1 The concomitant injection of 1 \u00d7 10\u20138 mol pyrilamine with 50 \u00b5g PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1 did not suppress the above-mentioned parameter, while 5 \u00d7 10-8 mol pyrilamine significantly suppressed it. Diphenhydramine suppressed the PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1-induced hyperglycemia to a greater extent than did pyrilamine. In contrast, concomitant injection of the H&lt;sub&gt;1&lt;\/sub&gt; receptor antagonist ranitidine (1 \u00d7 10\u20138, 5 \u00d7 10\u20138 mol) did not suppress the hyperglycemia induced by PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1. The concomitant injection of 5 \u00d7 10\u20138 mol diphenhydramine or pyrilamine with 50 \u00b5g PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1 significantly suppressed the increase in plasma epinephrine induced by PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1, but the same dose of ranitidine had no effect. The concomitant injection of atropine (5 \u00d7 10\u20138, 5 \u00d7 10\u20137 mol) with 50 \u00b5g PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1 significantly suppressed the increase in hepatic plasma glucose and epinephrine induced by PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1. These findings demonstrate that PGF&lt;sub&gt;2&lt;\/sub&gt;\u03b1-induced hyperglycemia is mediated by the muscarinic receptors of cholinoceptive neurons and in part by H&lt;sub&gt;1&lt;\/sub&gt; receptors in the central nervous system.<\/jats:p>","DOI":"10.1159\/000126354","type":"journal-article","created":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T06:52:44Z","timestamp":1207637564000},"page":"146-151","source":"Crossref","is-referenced-by-count":4,"title":["Involvement of Central Cholinergic Muscarinic Receptors and Histamine H\n                    <sub>1<\/sub>\n                    Receptors in Hyperglycemia Induced by Prostaglandin F\n                    <sub>2<\/sub>\n                    \u03b1 in Rats"],"prefix":"10.1159","author":[{"given":"Katsunori","family":"Nonogaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Xian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Kunoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Tamagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,8]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/126354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000126354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:34:50Z","timestamp":1777664090000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000126354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000126354","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,8]]}}}