{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:53:11Z","timestamp":1777920791292,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T00:00:00Z","timestamp":1207612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T00:00:00Z","timestamp":1207612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of naloxone, an opioid receptor antagonist, at a rate of 1.0 mg\/kg\/h for 2 h resulted in shorter (p &lt; 0.05) intervals between MUA volleys than during the control period (61.6 \u00b1 0.7 vs. 92.5 \u00b1 7.2 min) in animals treated with progesterone and estradiol that had reproduced a steroidal milieu during the luteal phase. Similarly, in the absence of steroidal treatment, the interval between MUA volleys was shortened (p &lt; 0.01) in a dose-dependent manner from 42.3 \u00b1 3.7 min (control) to 35.1 \u00b1 3.9,32.6 \u00b1 4.1, and 27.0 \u00b1 1.7 min when infused with 0.2, 1.0, and 5.0 mg\/kg\/h of naloxone, respectively. On the other hand, the duration of each MUA volley was lengthened by naloxone. The results indicate that the hypothalamic gonadotropin-releasing hormone pulse generator activity is under a tonic suppression by endogenous opioid peptides in ovariectomized goats.<\/jats:p>","DOI":"10.1159\/000126418","type":"journal-article","created":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T06:52:44Z","timestamp":1207637564000},"page":"634-639","source":"Crossref","is-referenced-by-count":16,"title":["Opioid Peptidergic Control of Gonadotropin-Releasing Hormone Pulse Generator Activity in the Ovariectomized Goat"],"prefix":"10.1159","author":[{"given":"Kazumi","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Tanak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,8]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/126418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000126418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:35:47Z","timestamp":1777664147000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000126418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000126418","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,8]]}}}