{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:55:48Z","timestamp":1777920948992,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,4,9]],"date-time":"2008-04-09T00:00:00Z","timestamp":1207699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,9]],"date-time":"2008-04-09T00:00:00Z","timestamp":1207699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>Possible interactions of ACTH-like peptides with melatonin regulation of central-type benzodiazepine (BNZ) receptors have been studied by means of highaffinity 3H-fiunitrazepam binding to rat cerebral cortex membrane preparations. Intracerebroventricular injections of melatonin produce a dose-dependent increase in B&lt;sub&gt;max&lt;\/sub&gt; in pinealectomized rats, without changes in K&lt;sub&gt;D&lt;\/sub&gt;. Analogous effects were obtained after intracerebroventricular injection of melatonin in adrenalectomized and in adrenalectomized plus pinealectomized rats, which indicated the lack of participation of adrenal steroids in this response. Moreover, intracerebroventricular injection of ACTH&lt;sub&gt;1\u201310&lt;\/sub&gt; induced a similar dose-dependent increased B&lt;sub&gt;max&lt;\/sub&gt; in sham-operated animals, whereas pinealectomy, but not adrenalectomy, partially counteracted this effect of ACTH&lt;sub&gt;1\u201310&lt;\/sub&gt; administration. Besides, simultaneous injection of ACTH&lt;sub&gt;1\u201310&lt;\/sub&gt; plus melatonin reverses the effects of pinealectomy, resulting in an additive effect of both compounds on B&lt;sub&gt;max&lt;\/sub&gt;. The response obtained when using ACTH&lt;sub&gt;4\u201310&lt;\/sub&gt; was somewhat different, because no dose response was obtained in any experiment. Although lack of endogenous melatonin partially reduced the increasing effect of ACTH&lt;sub&gt;4\u201310&lt;\/sub&gt; on B&lt;sub&gt;max&lt;\/sub&gt;, there were no additive effects at the different doses used. The results strongly suggest that ACTH-like peptides, in addition to melatonin, play a role in regulating central-type rat BNZ receptors.<\/jats:p>","DOI":"10.1159\/000126767","type":"journal-article","created":{"date-parts":[[2008,4,10]],"date-time":"2008-04-10T04:37:20Z","timestamp":1207802240000},"page":"252-260","source":"Crossref","is-referenced-by-count":13,"title":["Influence of the Behaviorally Active Peptides ACTH\n                    <sub>1\u201310<\/sub>\n                    , and ACTH\n                    <sub>4\u201310<\/sub>\n                    on the Melatonin Modulation of\n                    <sup>3<\/sup>\n                    H-Flunitrazepam Receptor Binding in the Rat Cerebral Cortex"],"prefix":"10.1159","author":[{"given":"Maria Dolores","family":"Gomar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Maria","family":"del Aguila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"de Dios Luna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Acu\u00f1a Castroviejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,9]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/126767","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000126767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:40:36Z","timestamp":1777664436000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000126767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000126767","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,9]]}}}