{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:30:28Z","timestamp":1773833428175,"version":"3.50.1"},"reference-count":31,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Bone and mineral disorders may contribute to extraosseous ossifications and cardiovascular disease (CVD) in end-stage renal disease (ESRD) patients. We have investigated the relationship between bone mineral density (BMD) and inflammation, wasting, CVD and mortality in ESRD patients. &lt;i&gt;Methods:&lt;\/i&gt; BMD (dual energy X-ray absorptiometry) and biochemical, nutritional and inflammatory markers were assessed in 277 incident ESRD patients (GFR 7.1 \u00b1 0.2 ml\/min) who were then followed prospectively for a mean of 27 (range 1\u201360) months. Carotid plaques were determined in 103 patients. &lt;i&gt;Results:&lt;\/i&gt; Patients with carotid plaques, clinical manifestation of CVD and wasting (assessed by subjective global assessment) had significantly lower BMD than their counterparts. Low BMD was associated with high all-cause and cardiovascular mortality. Even after adjustment for several confounders and risk factors, all-cause (HR = 2.1, CI: 1.1\u20133.9, p = 0.02) and cardiovascular (HR = 2.8, CI: 1.2\u20136.3, p = 0.02) mortality remained significantly associated with low BMD. &lt;i&gt;Conclusions:&lt;\/i&gt; Low BMD is associated with wasting and CVD, and is an independent predictor of all-cause and cardiovascular mortality in ESRD patients.<\/jats:p>","DOI":"10.1159\/000126925","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T12:55:49Z","timestamp":1208523349000},"page":"284-290","source":"Crossref","is-referenced-by-count":20,"title":["Bone Mineral Density in End-Stage Renal Disease Patients: Association with Wasting, Cardiovascular Disease and Mortality"],"prefix":"10.1159","volume":"26","author":[{"given":"Keisuke","family":"Matsubara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed 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