{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:57:11Z","timestamp":1745470631374,"version":"3.40.4"},"reference-count":44,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; The effect of isocaloric diets and sibutramine on dietary behaviour and TNF-\u03b1 is poorly understood. The aim of the study was to investigate the effects of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-\u03b1 in free-feeding rats. &lt;i&gt;Methods:&lt;\/i&gt; Three groups of male Wistar rats (n = 63) were fed a high-fat diet, high-carbohydrate diet or high-protein diet for 13 weeks. In the last 3 weeks, each group was divided into 3 subgroups. Each subgroup received sibutramine 5 mg\/kg, sibutramine 10 mg\/kg or vehicle. Food intake was measured daily during the last week of the experiment; serum TNF-\u03b1 was assayed and the body weight increasing rate was calculated. &lt;i&gt;Results:&lt;\/i&gt; The high-fat diet was associated with increased food intake, a greater weight gain ratio and increased TNF-\u03b1 levels. Sibutramine treatment did not affect the dietary behaviour of high-protein- or high-carbohydrate-fed rats, while it significantly attenuated the daily food intake and body weight gain rate in the high-fat group, at the dose of 10 mg\/kg. TNF-\u03b1 levels were not affected by sibutramine. &lt;i&gt;Conclusions:&lt;\/i&gt; High-fat feeding was associated with an increase in daily food intake, TNF-\u03b1 levels and body weight gain rate, as well as with enhanced responsiveness to the anorectic effects of sibutramine. However, sibutramine did not affect TNF-\u03b1.<\/jats:p>","DOI":"10.1159\/000127363","type":"journal-article","created":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T11:20:49Z","timestamp":1208949649000},"page":"15-21","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Isocaloric Diets and Sibutramine on Food Intake, Body Mass Variation and Serum TNF-\u03b1 Levels in 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