{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:02:12Z","timestamp":1761512532456,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This retrospective cohort study included patients with ovarian cancer in relapse. During a first period (1998\u20132001), 24 patients received the standard topotecan dose of 1.5 mg\/m&lt;sup&gt;2&lt;\/sup&gt;\/day for 5 consecutive days with a 3-week interval between each treatment course. During a second period (2003\u20132006), 21 patients received a weekly topotecan dose of 4 mg\/m&lt;sup&gt;2&lt;\/sup&gt; for 3 weeks out of every 4. Grades III and IV haematological toxicities were more frequent with the standard strategy (p &lt; 0.05), even after adjustment of the prescription of erythropoietin and G-CSF. With the weekly strategy, an increase in dose density and a reduction in the number of delayed doses were observed. No significant difference between the 2 strategies was found in terms of response to the treatment and specific survival. This study suggests that the weekly administration of topotecan 4 mg\/m&lt;sup&gt;2&lt;\/sup&gt;, for 3 weeks out of every 4, results in a better maintenance of dose density and a reduction in haematological toxicity.<\/jats:p>","DOI":"10.1159\/000127384","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T09:12:51Z","timestamp":1208423571000},"page":"177-184","source":"Crossref","is-referenced-by-count":12,"title":["Haematological Evaluation of Weekly Therapy with Topotecan for the Treatment of Recurrent Ovarian Cancer Resistant to Platinum-Based Therapy"],"prefix":"10.1159","volume":"73","author":[{"given":"R.","family":"Largillier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Valenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-M.","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Novo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Creisson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lesbats","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Mari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Chamorey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322%2Fcanjclin.57.1.43"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199601043340101"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2909738-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1081%2FCNV-120016409"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902440307"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.1.59"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-2237-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01288-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/382363a0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2012.08171.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(90)90111-G"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90921-U"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00384-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2803%2901087-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00559-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(97)00070-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2Fdjj296"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.2.133"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/127384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/127384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:23:43Z","timestamp":1745461423000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000127384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":18,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000127384","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2007]]}}}