{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:20:44Z","timestamp":1777868444978,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T00:00:00Z","timestamp":1208217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T00:00:00Z","timestamp":1208217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"abstract":"<jats:p>In the course of clinical investigation of a new higher molecular weight plasma substitute made of gelatin (MW 60,000), severe side reactions were observed in 2 patients. As the erythrocyte sedimentation rate was markedly raised in both patients after the gelatin infusion, it was thought that these reactions might result from the effect of the gelatin solution on red cell aggregation. The effect of gelatin solutions on red cell aggregation was studied in vitro on human blood and in vivo in dogs using the erythrocyte sedimentation rate and an optical density method to assess its degree. It was shown by all methods that the high molecular weight gelatin fraction induced marked red cell aggregation and it has been concluded that the present gelatin solution cannot be recommended for use in clinical practice.<\/jats:p>","DOI":"10.1159\/000127589","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T05:12:51Z","timestamp":1208409171000},"page":"428-435","source":"Crossref","is-referenced-by-count":3,"title":["Red Cell Aggregation Induced by a High Molecular Weight Gelatin Plasma Substitute"],"prefix":"10.1159","volume":"3","author":[{"given":"P.M.","family":"Scholz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Engeset","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.A.","family":"Matheson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.F.","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,15]]},"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000127589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:57:38Z","timestamp":1777550258000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000127589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,15]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1971,6,1]]},"published-print":{"date-parts":[[1971,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000127589","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,15]]}}}