{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:21:35Z","timestamp":1777868495715,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T00:00:00Z","timestamp":1208476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T00:00:00Z","timestamp":1208476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"abstract":"<jats:p>The effect of prostaglandins (PGs), i.e. PGE&lt;sub&gt;1&lt;\/sub&gt; PGE&lt;sub&gt;2&lt;\/sub&gt; and PGF&lt;sub&gt;2\u03b1&lt;\/sub&gt; (0.5\u201332 \u00b5g\/kg), on the electrical activity of the rabbit sphincter of Oddi was studied in vivo. PGs were injected intravenously as a bolus and electrical activity of the sphincter and the duodenum was recorded before and during 15 min after the injection. Variations in biliary pressure were also studied at the same time. PGE&lt;sub&gt;1 &lt;\/sub&gt;strongly decreased the activity of the sphincter and biliary pressure which were both increased by PGF&lt;sub&gt;2\u03b1&lt;\/sub&gt;\u00b7Both PGE&lt;sub&gt;1&lt;\/sub&gt; and PGF&lt;sub&gt;2\u03b1&lt;\/sub&gt; showed a dose-response curve of Michaelis-Menten type. Unexpectedly PGE&lt;sub&gt;2&lt;\/sub&gt; increased at first then decreased electrical activity but not significantly. These effects appeared very early after intravenous injection and were evident with low doses.<\/jats:p>","DOI":"10.1159\/000128376","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T08:55:49Z","timestamp":1208508949000},"page":"322-327","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Prostaglandins E\n                    <sub>1<\/sub>\n                    E\n                    <sub>2<\/sub>\n                    and F\n                    <sub>2\u03b1<\/sub>\n                    on the Electric Activity of the Sphincter of Oddi in Living Rabbit"],"prefix":"10.1159","volume":"15","author":[{"given":"E.","family":"Martinez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Sarles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,18]]},"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000128376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:01:45Z","timestamp":1777550505000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000128376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,18]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1983,6,1]]},"published-print":{"date-parts":[[1983,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000128376","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,18]]}}}