{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:21:54Z","timestamp":1777868514176,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2008,4,22]],"date-time":"2008-04-22T00:00:00Z","timestamp":1208822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,4,22]],"date-time":"2008-04-22T00:00:00Z","timestamp":1208822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"abstract":"<jats:p>Gastric ulceration has been induced after stress, combining 24 h of fasting and 48 h of restraint in 9 groups of 20 rats with or without a pyloroplasty or a pylorojejunostomy combined with atropine and gastric infusion of NaHCO&lt;sub&gt;3&lt;\/sub&gt; or taurocholic acid. After death or sacrifice at 48 h, ulcer index and blood in the jejunum were determined. Gastric mucosal blood flow was measured semi-continuously by a laser Doppler velocimeter. There were 45% deaths after 48 h of restraint alone, and 70% in the group combining pylorojejunostomy with taurocholic acid. Mortality was lower (p \u2264 0.01) with pylorojejunostomy alone and more significantly so (p \u2264 0.001) when associated with NaHCO&lt;sub&gt;3&lt;\/sub&gt;. There was no death when NaHCO&lt;sub&gt;3&lt;\/sub&gt; and atropine were combined with restraint. The mucosal blood flow increased significantly during the first 12 h of restraint in the taurocholic acid group. Both groups with NaHC&lt;sub&gt;O&lt;\/sub&gt;3 had mucosal blood flows similar to the controls. Gastric acid and gastric emptying, mucosal ischemia and bile reflux are joint factors inducing gastric stress ulcer. The 100% survival and the low ulcer index after a treatment by atropine and gastric infusion of NaHCO&lt;sub&gt;3 &lt;\/sub&gt;suggest that these well-known drugs should be used more frequently.<\/jats:p>","DOI":"10.1159\/000128521","type":"journal-article","created":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T07:20:49Z","timestamp":1208935249000},"page":"159-168","source":"Crossref","is-referenced-by-count":1,"title":["Gastric Stress Ulcer of the Rat: Relative Contribution of the Pyloric Sphincter, HCO\n                    <sub>3<\/sub>\n                    Bile Reflux and Mucosal Blood Flow"],"prefix":"10.1159","volume":"18","author":[{"given":"R.","family":"B\u00e9nichoux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Durlik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mainard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,22]]},"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000128521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:03:07Z","timestamp":1777550587000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000128521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,22]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[1986,12,31]]},"published-print":{"date-parts":[[1986,12,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000128521","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,22]]}}}