{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:05:08Z","timestamp":1773270308504,"version":"3.50.1"},"reference-count":9,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Quantitative fluorescent polymerase chain reaction (QF-PCR) is a successful prenatal diagnostic method which has been regularly used for the diagnosis of common chromosomal abnormalities in recent years. This method provides diagnosis of common aneuploidies in a few hours after sampling with a high throughput, very low error rates and low cost. &lt;i&gt;Methods:&lt;\/i&gt; In this study, 576 amniotic fluid samples were analyzed for trisomies 13, 18, and 21 and sex chromosome aneuploidies using different commercial QF-PCR kits (ChromoQuant\u2122 version 1, Aneufast\u2122, ChromoQuant\u2122 version 2). Test results were compared with those obtained by conventional cytogenetic analyses. &lt;i&gt;Results:&lt;\/i&gt; Nine cases of trisomy 21 (1.6%), 1 case of trisomy 13 (0.17%), 3 cases of trisomy 18 (0.52%), 1 case of Turner syndrome (0.17%), 2 cases of Klinefelter\u2019s syndrome (0.34%), 2 cases of triploidy (0.34%) and 1 case of XXX (0.17%) were detected by QF-PCR. The results obtained by QF-PCR were consistent with the results of cytogenetic studies (except for 2 samples which had structural chromosomal abnormalities which could not be detected by QF-PCR). &lt;i&gt;Conclusion:&lt;\/i&gt; The QF-PCR method is an appropriate choice for rapid aneuploidy testing in our as well as in other populations.<\/jats:p>","DOI":"10.1159\/000128598","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T09:45:53Z","timestamp":1209548753000},"page":"104-110","source":"Crossref","is-referenced-by-count":11,"title":["Rapid Prenatal Diagnosis of Common Aneuploidies in Amniotic Fluid Using Quantitative Fluorescent Polymerase Chain Reaction"],"prefix":"10.1159","volume":"66","author":[{"given":"Huseyin","family":"Onay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timur","family":"Ugurlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayca","family":"Aykut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sacide","family":"Pehlivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Inal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivekar","family":"Tinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cihangir","family":"Ozkinay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferda","family":"Ozkinay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F2.1.43"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fmolehr%2F7.10.1001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2801%2906183-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.57"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fnar%2Fgnf056"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.569"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1247"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1089"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ejhg.5201224"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/128598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/128598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:20:06Z","timestamp":1745457606000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000128598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000128598","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}