{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:48:28Z","timestamp":1790272108628,"version":"4.1.0"},"reference-count":44,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; The aim of this study was to investigate the serotonin transporter (SERT), by means of the &lt;sup&gt;3&lt;\/sup&gt;H-paroxetine ([&lt;sup&gt;3&lt;\/sup&gt;H]-Par) binding to platelet membranes, in patients affected by pathological gambling (PG), as compared with a similar group of healthy control subjects. &lt;i&gt;Methods:&lt;\/i&gt; Seventeen PG patients were selected amongst those who were drug-free and at the first psychiatric interview in a Department of Addiction. The diagnosis was assessed according to DSM-IV criteria and PG severity was measured by means of the South Oaks Gambling Screen. The platelet [&lt;sup&gt;3&lt;\/sup&gt;H]-Par binding was carried out according to a standardized method. The binding parameters, the maximum binding capacity (B&lt;sub&gt;max&lt;\/sub&gt;) and the dissociation constant (K&lt;sub&gt;d&lt;\/sub&gt;), were obtained by means of the Scatchard analysis. &lt;i&gt;Results:&lt;\/i&gt; The B&lt;sub&gt;max&lt;\/sub&gt; values of PG patients were significantly lower than that of healthy subjects, while the K&lt;sub&gt;d&lt;\/sub&gt; values were not different in the two groups. No significant effect of age, sex or psychiatric comorbidity on B&lt;sub&gt;max&lt;\/sub&gt; or K&lt;sub&gt;d&lt;\/sub&gt; was observed; there were also no correlations between clinical and biological variables. &lt;i&gt;Conclusions:&lt;\/i&gt; PG patients showed a dysfunction at the level of the platelet SERT that would suggest the involvement of the 5-HT system in this condition.<\/jats:p>","DOI":"10.1159\/000129665","type":"journal-article","created":{"date-parts":[[2008,5,6]],"date-time":"2008-05-06T14:30:07Z","timestamp":1210084207000},"page":"38-43","source":"Crossref","is-referenced-by-count":27,"title":["Decreased Density of the Platelet Serotonin Transporter in Pathological 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