{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:33:30Z","timestamp":1756996410687,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1962,1,1]],"date-time":"1962-01-01T00:00:00Z","timestamp":-252460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1962,1,1]],"date-time":"1962-01-01T00:00:00Z","timestamp":-252460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[1962]]},"abstract":"<jats:p>The chromosomes were studied in four patients with Marfan\u2019s syndrome, three male and one female, and, for comparison, in ten normal males. The karyotypes of the patients with Marfan\u2019s syndrome were normal in their general features, but systematic analysis of the lengths of chromosomes 1\u20132, the Y, and 21\u201322 revealed that the chromosomes 21\u201322 of the patients were relatively shorter than those of normal persons (Table I). The Y of the three male patients with Marfan\u2019s syndrome also varied, in one it was longer (Fig. 1), and in another shorter, than in the controls. The statistical significance of these findings was tested (Tables II\u2013VII). It was concluded that, at least in the cases of chromosomes 21\u201322, genotypic control of chromosome length, rather than structural variation, was underlying the differences observed between the patients with Marfan\u2019s syndrome and the normal controls.<\/jats:p>","DOI":"10.1159\/000129709","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T09:35:09Z","timestamp":1209548109000},"page":"5-19","source":"Crossref","is-referenced-by-count":34,"title":["Abnormal Length of Chromosomes 21 and 22 in Four Patients with Marfan\u2019s Syndrome"],"prefix":"10.1159","volume":"1","author":[{"given":"B.","family":"K\u00e4ll\u00e9n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Levan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,29]]},"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/129709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/129709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:31:27Z","timestamp":1745458287000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000129709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000129709","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"type":"print","value":"1424-8581"},{"type":"electronic","value":"1424-859X"}],"subject":[],"published":{"date-parts":[[1962]]}}}