{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:18:24Z","timestamp":1777763904880,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T00:00:00Z","timestamp":1210723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T00:00:00Z","timestamp":1210723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Cell Genet"],"abstract":"<jats:p>Sex-chromosomal aneuploidy was identified in four female progeny of 200 interspecific backcrosses between laboratory mice (C57BL\/6Ros) and Mus spretus. The progeny included two 39, XO monosomy mice resulting from a backcross with M. spretus, as well as a 41, XXX trisomic mouse and a 40, XX\/41, XXX mosaic mouse resulting from two separate backcrosses with C57BL\/6 mice. The parental origin and meiotic stage of the aneuploidies was determined for each of the mice using a series of markers that identified allelic differences in the parental X-chromosome genes present in the hybrid female. Two of the probes identified differences in repeated elements between the M. spretus and laboratory mouse X chromosomes, whereas the remaining sites involved restriction fragment length differences of single-copy genes detectable by Southern analysis. These markers indicated that the aneuploidies were most likely of maternal origin and that the trisomy resulted from a nondisjunction at the second meiotic division. In contrast, the mosaic female could have originated either from a trisomic embryo that had lost a single X in a portion of its cells or from a mitotic nondisjunction during early embryogenesis that resulted in XXX and XO daughter cells, with subsequent loss of the XO cells.<\/jats:p>","DOI":"10.1159\/000133299","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T06:04:53Z","timestamp":1210745093000},"page":"74-78","source":"Crossref","is-referenced-by-count":15,"title":["Analysis of sex-chromosome aneuploidy in interspecific backcross progeny between the laboratory mouse strain C57BL\/6 and Mus spretus"],"prefix":"10.1159","author":[{"given":"Y.","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.M.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,5,14]]},"container-title":["Cytogenetics and Cell Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/133299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000133299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:57:02Z","timestamp":1777474622000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000133299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000133299","archive":["Portico"],"relation":{},"ISSN":["0301-0171","1421-9816"],"issn-type":[{"value":"0301-0171","type":"print"},{"value":"1421-9816","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,14]]}}}