{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:11:31Z","timestamp":1791576691955,"version":"4.3.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background\/Aims:<\/i> Recent studies suggest that vitamin D metabolites may be important for preserving cognitive function via specific neuroprotective effects. No large studies have examined the association between vitamin D status and cognition. <i>Methods:<\/i> In this cross-sectional study, we analyzed the serum 25-hydroxyvitamin D<sub>3<\/sub> levels and Mini-Mental State Examination (MMSE) test scores of 225 older outpatients who were diagnosed as having probable Alzheimer\u2019s disease (AD). In addition to the 25-hydroxyvitamin D<sub>3<\/sub> levels, we analyzed the serum vitamin B<sub>1<\/sub>, B<sub>6<\/sub> and B<sub>12<\/sub> levels. <i>Results:<\/i> An association was found between MMSE test scores and serum 25-hydroxyvitamin D<sub>3<\/sub> levels, with a \u03b2-coefficient of 0.05 (p = 0.01). Vitamin-D-sufficient patients had significantly higher MMSE scores as compared to vitamin-D-insufficient ones. No association was found with the other serum vitamin levels. <i>Conclusions:<\/i> These data support the idea that a relationship exists between vitamin D status and cognition in patients with probable AD. However, given the cross-sectional design of this study, no causality can be concluded. Further prospective studies are needed to specify the contribution of vitamin D status to the onset and course of cognitive decline and AD.<\/jats:p>","DOI":"10.1159\/000134382","type":"journal-article","created":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T09:23:00Z","timestamp":1211534580000},"page":"539-543","source":"Crossref","is-referenced-by-count":117,"title":["Higher Serum Vitamin D<sub>3<\/sub> Levels Are Associated with Better Cognitive Test Performance in Patients with Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"25","author":[{"given":"C.","family":"Oudshoorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.U.S.","family":"Mattace-Raso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"van der Velde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Colin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.J.M.","family":"van der Cammen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000111150"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1192%2Fbjp.150.3.359"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS1043-2760%2801%2900547-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pbiomolbio.2006.02.016"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jsbmb.2006.12.016"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jchemneu.2004.08.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.abb.2006.12.018"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.22.4.477"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra070553"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fendo-118-4-1433"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jsbmb.2005.06.002"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ejcn.1602111"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000110738"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0169-328X%2892%2990032-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.2004.19.2.265"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2004.07.008"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1532-5415.2007.01482.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.163.18.2219"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/134382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/134382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:43:16Z","timestamp":1745458996000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000134382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2008,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000134382","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}