{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:32:37Z","timestamp":1777764757046,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T00:00:00Z","timestamp":1211241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T00:00:00Z","timestamp":1211241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Cell Genet"],"abstract":"<jats:p>We examined the stability of different types of DNA microsatellite markers in \u03b3-radiation-induced thymic lymphomas as well as normal, nontumorous tissues of F&lt;sub&gt;1&lt;\/sub&gt; hybrid mice derived from the parental strains C57BL\/6J, RF\/J, and BALB\/cJ. Surprisingly, the D4Mit12 microsatellite showed genomic instability in a significant fraction of DNAs of the (C57BL\/6J \u00d7 BALB\/cJ) F&lt;sub&gt;1&lt;\/sub&gt; hybrids with independence of the tumor phenotype. This instability was not found in the reciprocal F&lt;sub&gt;1&lt;\/sub&gt; DNAs, in DNAs of the parental strains, or in DNAs of (C57BL\/6J \u00d7 RF\/J) F&lt;sub&gt;1&lt;\/sub&gt; hybrid mice. These results suggest that the instability of the D4Mitl2 microsatellite is dependent on its repeat length, the genetic background of F&lt;sub&gt;1&lt;\/sub&gt; hybrids, and the maternal origin of the C57BL\/6J allele.<\/jats:p>","DOI":"10.1159\/000134661","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T10:14:19Z","timestamp":1211364859000},"page":"221-223","source":"Crossref","is-referenced-by-count":0,"title":["Instability of the D4Mit12 microsatellite marker in C57BL\/6J \u00d7 BALB\/cJ F\n                    <sub>1<\/sub>\n                    hybrid mice is independent of the tumor phenotype"],"prefix":"10.1159","author":[{"given":"M.","family":"Herranz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"P\u00e9rez de Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Mel\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J..","family":"Fern\u00e1ndez-Piqueras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,5,20]]},"container-title":["Cytogenetics and Cell Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/134661","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000134661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:09:55Z","timestamp":1777475395000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000134661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000134661","archive":["Portico"],"relation":{},"ISSN":["0301-0171","1421-9816"],"issn-type":[{"value":"0301-0171","type":"print"},{"value":"1421-9816","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,20]]}}}