{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:35:22Z","timestamp":1791264922466,"version":"4.1.0"},"reference-count":32,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>In this paper, we investigated Cdx2 and claudin-2 expression in pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy to determine the correlation between the expressions of these 2 genes during gastric carcinogenesis by immunochemical ABC technique. Altogether, we analyzed 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples. Our results indicated that the percentage of Cdx2-positive cases was 0% (0\/108) for chronic superficial gastritis, 0% (0\/55) for chronic atrophic gastritis, 90.83% (99\/109) for intestinal-type metaplasia, 51.61% (48\/93) for dysplasia and 61.54% (32\/52) for gastric intestinal-type adenocarcinoma, primarily expressed in the cell nucleus and partly in the cytoplasm (p &lt; 0.05); interestingly, the percentage for the intestine-type metaplasia was markedly high. The percentage of claudin-2-positive cases was 0% (0\/108) for chronic superficial gastritis, 0% (0\/55) for chronic atrophic gastritis, 0% (0\/109) for intestinal-type metaplasia, 35.48% (33\/93) for dysplasia and 71.15% (37\/52) for gastric intestinal-type adenocarcinoma, primarily in the cell membrane and gradually increased in the multistage process of gastric carcinogenesis (p &lt; 0.05). Significant correlations were found between claudin-2 and Cdx2 protein expression in dysplasia and intestine-type adenocarcinoma (r = 0.112, p &lt; 0.05). Thus, there may be a correlation between the expression of claudin-2 and Cdx2 in stages of dysplasia and cancer.<\/jats:p>","DOI":"10.1159\/000135351","type":"journal-article","created":{"date-parts":[[2008,5,26]],"date-time":"2008-05-26T13:38:42Z","timestamp":1211809122000},"page":"357-365","source":"Crossref","is-referenced-by-count":32,"title":["Expression of Cdx2 and Claudin-2 in the Multistage Tissue of Gastric Carcinogenesis"],"prefix":"10.1159","volume":"73","author":[{"given":"Song","family":"Xin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Huixin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Benchang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai","family":"Aiping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Jinhui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiaoyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wong Benjamin Chun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Minhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0630649100"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.149.1.13"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.143.2.391"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.147.4.891"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.285.5424.103"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2F35067088"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1242%2Fjcs.00165"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M110261200"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.2.12a.1647"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrc1141"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00428-004-1157-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3835%2801%2900753-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199610000-00001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-200002000-00001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.33.9.801"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01296393"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2559.2005.02127.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2407-2-37"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-291X%2802%2900480-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0215%2819970220%2974%3A1%3C35%3A%3AAID-IJC7%3E3.0.CO%3B2-1"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F01.MP.0000086073.92773.55"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2F386084a0"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.22.14030"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.96.2.511"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2003.07607.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.addr.2005.01.008"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2001.21736"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2890%2990257-F"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002%2Fjcp.20189"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yexcr.2004.06.011"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tim.2003.11.005"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.147.1.195"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/135351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/135351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:22:50Z","timestamp":1745457770000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000135351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":32,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2008,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000135351","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}