{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:54:30Z","timestamp":1745470470299,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> We noted that several patients presenting with both localized vulvodynia (vulvar vestibulitis) and peptic symptoms reported a resolution of dyspareunia after receiving a full treatment course for <i>Helicobacter pylori<\/i>. <i>Methods:<\/i> Women with localized vulvodynia were interviewed regarding symptoms of peptic disease. Those with peptic symptoms underwent a blood test for the presence of antibodies to <i>H. pylori<\/i> and were referred to a gastroenterology consultation. In all women, vestibular biopsies were obtained and stained for <i>H. pylori<\/i>. Healthy vestibular tissues as well as archival negative and positive gastric tissues served as controls. <i>Results:<\/i> Of the blood antibody tests, 12 (80%) were positive. None of the patients had evidence of <i>H. pylori<\/i> in the vestibule. Eleven women received triple therapy for eradication of <i>H. pylori<\/i>. Eight (73%) reported complete relief of dyspareunia and of gastric symptoms. <i>Conclusion:<\/i> Our study found no immunohistochemical evidence of <i>H. pylori<\/i> infection in the vestibule but suggested a possible role for anti-<i>H. pylori<\/i> treatment in localized vulvodynia.<\/jats:p>","DOI":"10.1159\/000135712","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T09:40:33Z","timestamp":1212745233000},"page":"152-156","source":"Crossref","is-referenced-by-count":2,"title":["A Search for <i>Helicobacter pylori<\/i>in Localized Vulvodynia"],"prefix":"10.1159","volume":"66","author":[{"given":"Adam","family":"Geva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond","family":"Sabo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Blumenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Ophir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Geva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Bornstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2898%2900535-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00004347-198809000-00005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00004347-199801000-00002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199502000-00004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000079663"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0301-2115%2896%2902502-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2897%2900719-9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000010045"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1067%2FS0002-9378%2803%2900790-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra020542"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0928-4257%2800%2900160-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10067-006-0416-x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.1999.01214.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.39.11.1279-a"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.1998.00223.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.41.4.442"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2006.12.038"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2002.121869"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2896%2970263-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.gtc.2006.03.004"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/135712","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/135712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:26:01Z","timestamp":1745457961000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000135712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000135712","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2008]]}}}