{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:49:59Z","timestamp":1777945799733,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T00:00:00Z","timestamp":1211932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T00:00:00Z","timestamp":1211932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>Investigations of effects exerted by various compounds on hepatic microsomal mixed function oxidases are frequently designed for and performed under a single set of conditions with respect to dosage and time of sacrifice after drug administration. From these data a generalization may be derived as to whether a particular drug inhibits, induces or produces no change in these enzymes. Limitations of this approach are illustrated by experiments with GPA 1851, an imidazolone derivative with anti-inflammatory properties. Two hours after a single oral dose of 50 mg\/kg, rat hepatic microsomal aniline hydroxylase and ethylmorphine N-demethylase activities were markedly reduced, whereas if the rats were sacrificed 24 h after this oral dose, aniline hydroxylase activity and cytochrome P-450 were enhanced. When rats were sacrificed 24 h after the last of 4 daily oral doses of GPA 1851, no significant change occurred in aniline hydroxylase or ethylmorphine N-demethylase activities, but cytochrome P-450 content was elevated.<\/jats:p>","DOI":"10.1159\/000136337","type":"journal-article","created":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T07:26:06Z","timestamp":1212391566000},"page":"217-221","source":"Crossref","is-referenced-by-count":6,"title":["Differential Effects of GPA 1851 on Hepatic Microsomal Drug Metabolism Dependent on Dosage and Time of Sacrifice"],"prefix":"10.1159","author":[{"given":"E.S.","family":"Vesell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.T.","family":"Passananti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.A.","family":"Shively","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,5,28]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/136337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000136337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:28:57Z","timestamp":1777728537000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000136337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000136337","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,28]]}}}