{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:51:38Z","timestamp":1777945898894,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T00:00:00Z","timestamp":1211932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T00:00:00Z","timestamp":1211932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>Chlorpromazine produced a slowly developing, irreversible contracture of isolated frog rectus abdominis muscle. The contracture was unaffected by tubocurarine, hexamethonium, atropine, physostigmine, procaine, cocaine, ouabain, quinine, and sparteine. Bathing the muscles in calcium-deficient Ringer, Ringer-containing oxalate or choline-Ringer did not affect action of chlorpromazine, which was strongly reduced in potassium-depolarized muscle or by calcium-deficient Ringer containing EDTA. Nitrate-Ringer facilitated the contracture. Chlorpromazine seems to act not through a cholinergic mechanism or membrane depolarization but by releasing calcium, probably from transverse tubular sites or some other superficial site.<\/jats:p>","DOI":"10.1159\/000136518","type":"journal-article","created":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T07:26:06Z","timestamp":1212391566000},"page":"32-38","source":"Crossref","is-referenced-by-count":14,"title":["Chlorpromazine-Induced Contracture of Frog Rectus Abdominis Muscle"],"prefix":"10.1159","author":[{"given":"V.V.","family":"Kelkar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.B.","family":"Doctor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MN.","family":"Jindal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,5,28]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000136518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:33:13Z","timestamp":1777728793000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000136518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000136518","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,28]]}}}