{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:56:54Z","timestamp":1777946214115,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T00:00:00Z","timestamp":1212019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T00:00:00Z","timestamp":1212019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>The effects of prostaglandin E&lt;sub&gt;2&lt;\/sub&gt; (PGE&lt;sub&gt;2&lt;\/sub&gt;) have been studied on the gastric secretion and the serum level of immunoreactive gastrin in pylorus-ligated and antrectomized rats. It has been observed that: (1) a significant inhibition of gastric secretion (volume and acid output) was caused by PGE&lt;sub&gt;2&lt;\/sub&gt;, applied in doses of 75, 150 and 300 \u03bcg\/kg body weight, subcutaneously, in both pylorus-occluded and antrectomized rats: PGE&lt;sub&gt;2&lt;\/sub&gt; inhibition of gastric secretion was more pronounced in rats with antrectomy; (2) no significant changes were found in the serum gastrin levels of both pylorus-ligated and antrectomized rats, and (3) no significant changes in serum levels of immunoreactive gastrin were produced by different doses of PGE&lt;sub&gt;2&lt;\/sub&gt;, in comparison with their marked inhibitory effects on gastric H+ secretion. It was concluded that there is no essential role of the immunoreactive gastrin, originated from the antral part of the stomach, neither in development of gastric hypersecretion nor in PGE&lt;sub&gt;2&lt;\/sub&gt;-produced inhibition on gastric secretion of the pylorus-occluded rats.<\/jats:p>","DOI":"10.1159\/000136758","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T03:28:44Z","timestamp":1212118124000},"page":"135-141","source":"Crossref","is-referenced-by-count":5,"title":["Interrelationships between the Gastric Secretory Responses, Prostaglandin E\n                    <sub>2<\/sub>\n                    Inhibition and Serum Level of Immunoreactive Gastrin in Pylorus-Ligated and Antrectomized Rats"],"prefix":"10.1159","author":[{"given":"L.","family":"Nagy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy.","family":"M\u00f3zsik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"T\u00e1rnok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Szalai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"P\u00f3th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"J\u00e1vor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,5,29]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000136758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:35:30Z","timestamp":1777736130000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000136758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000136758","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,29]]}}}