{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:54:46Z","timestamp":1777946086285,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T00:00:00Z","timestamp":1212019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T00:00:00Z","timestamp":1212019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>The morphology of anterior pituitaries has been investigated by electron microscopy after administration of 2-bromo-\u03b1-ergocryptine (CB-154) in different experimental conditions. These include: a 1- to 5-week treatment (1 mg\/kg BW, daily) to rats and a 5-week treatment (0.3 mg\/kg BW, daily) to dogs, a single injection (2.5 mg\/kg BW, 4 h before autopsy) or a 15-day treatment (1 mg\/kg BW, daily) to hypophysectomized rats bearing an ectopic pituitary, a single injection (10 mg\/kg BW, 4 h before autopsy) to rats bearing the experimental MtW 15 tumor and an in vitro experiment with fragments of a human GH producing adenoma incubated for 2 h in a medium containing CB-154 (1 \u03bcg\/ml). Some possible explanations for the structural changes observed after CB-154 treatment are offered.<\/jats:p>","DOI":"10.1159\/000136820","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T03:28:44Z","timestamp":1212118124000},"page":"193-203","source":"Crossref","is-referenced-by-count":6,"title":["Effects of 2-Bromo-\u03b1-ergocryptine on the Ultrastructure of Anterior Pituitaries in Different Experimental Conditions"],"prefix":"10.1159","author":[{"given":"G.L.","family":"Rossi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,5,29]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000136820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:35:57Z","timestamp":1777736157000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000136820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000136820","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,29]]}}}