{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:56:55Z","timestamp":1777946215893,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T00:00:00Z","timestamp":1212019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T00:00:00Z","timestamp":1212019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>The various effects of histamine on smooth muscles and other tissues are thought to be mediated by two pharmacologically distinct receptors, H&lt;sub&gt;t&lt;\/sub&gt; and H&lt;sub&gt;2&lt;\/sub&gt; types. These receptors are defined in terms of their susceptibility to blockade by pyrilamine (type\u00edi!) or burimamide (typeH&lt;sub&gt;2&lt;\/sub&gt;). In this study selective antagonism of the spasmodic effects of histamine on isolated strips of rabbit detrusor has shown that the response is mediated by H&lt;sub&gt;1&lt;\/sub&gt; receptors, with no evidence of H&lt;sub&gt;2&lt;\/sub&gt; activity. The pA2 of the pyrilamine-histamine antagonism is 9.3. The histamine response is susceptible to muscarinic blockade (atropine and propantheline) but not to nicotinic blockade (hexamethonium). Adrenergic blocking agents propranolol (10\u20134M) and phenoxybenzamine (10\u20138M) do antagonize the contractile response, but this does not appear to be indicative of adrenergic mediation.<\/jats:p>","DOI":"10.1159\/000136879","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T03:28:44Z","timestamp":1212118124000},"page":"5-11","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of the Rabbit Detrusor Response to Histamine through Pharmacologic Antagonism"],"prefix":"10.1159","author":[{"given":"Christopher M.","family":"Fredericks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,5,29]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000136879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:36:34Z","timestamp":1777736194000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000136879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000136879","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,29]]}}}