{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:08:39Z","timestamp":1792084119179,"version":"4.4.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T00:00:00Z","timestamp":1212019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T00:00:00Z","timestamp":1212019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>Hyperthermia was elicited in rats by the subcutaneous injection of 4 mg\/kg (+)-amphetamine, 4 mg\/kg (+)-p-chloroamphetamine, or 8 mg\/kg fenfluramine. This hyperthermia could be abolished by oral pretreatment with 300 mg\/kg p-chlorophenylalanine. Cyproheptadine, at a dose of 0.05 mg\/kg, completely inhibited the response induced by p-chloroamphetamine, but a dose of 0.4 mg\/kg was necessary in the case of amphetamine and fenfluramine. Protection against hyperthermia by p-chloroamphetamine was also provided by chloroimipramine. Hypothalamic turnover of 5-HT was enhanced by all three amphetamines. \u03b1-Methyl\u00b7tyrosine and disulfiram had no effect on the hyperthermia induced by the amphetamines, FLA-63 seemed even to enhance it. Haloperidol, in the dose range of 0.1\u20130.4 mg\/kg, attenuated the hyperthermia induced by amphetamine and p-chloroamphetamine, but not that induced by fenfluramine. The results point to a central origin of the hyperthermia induced by amphetamine, p-chloroamphetamine and fenfluramine. In the mediation of this effect, 5-HT and, to a lesser degree, dopamine seem to play an important role.<\/jats:p>","DOI":"10.1159\/000136897","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T03:28:44Z","timestamp":1212118124000},"page":"163-176","source":"Crossref","is-referenced-by-count":46,"title":["Hyperthermia Induced by Amphetamine, p-Chloroamphetamine and Fenfluramine in the Rat"],"prefix":"10.1159","author":[{"given":"H.-H.","family":"Frey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,5,29]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000136897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:36:45Z","timestamp":1777736205000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000136897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000136897","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,29]]}}}