{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:27:12Z","timestamp":1770434832432,"version":"3.49.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Oral lichen planus (OLP) is a chronic inflammatory disease of unknown cause, which possesses the potential for malignant transformation. Cyclooxygenases (COX) 1 and 2 are two enzymes known to convert arachidonic acid into prostaglandins. Recent studies have shown an overexpression of COX-2 in oral squamous cell carcinoma and its precursor lesions. The present study investigated the expression of the COX-2 protein in OLP by Western blot analysis. Thirty patients with different degrees of histologically confirmed disease activity participated in the study: 9 patients had a recent onset of active OLP, 12 patients had atrophic OLP with moderate or low activity, and 9 patients presented with atrophic OLP with complete loss of activity. The results showed a high expression of COX-2 in all OLP patients in comparison with the control group. The differences in COX-2 expression in the various stages of OLP were not statistically significant. In conclusion, our results suggest that COX-2 is present during the various clinical forms of OLP. The resulting sustained overexpression of COX-2 in the late stage of the disease could play a role in the malignant transformation of some OLP.<\/jats:p>","DOI":"10.1159\/000137672","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T09:40:33Z","timestamp":1212745233000},"page":"150-155","source":"Crossref","is-referenced-by-count":25,"title":["COX-2 Expression in Oral Lichen Planus"],"prefix":"10.1159","volume":"217","author":[{"given":"Stella","family":"Lysitsa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacky","family":"Samson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Gerber-Wicht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177%2F10454411980090010501"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tripleo.2004.06.077"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.oraloncology.2003.08.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177%2F154411130201300405"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0030-4220%2868%2990194-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0714.2002.310510.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000073109"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000106592"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.162468699"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1368-8375%2803%2900035-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS1368-8375%2803%2900105-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.oraloncology.2004.09.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS1368-8375%2803%2900012-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0714.1993.tb00134.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS1368-8375%2898%2900116-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS1079-2104%2803%2900305-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053%2Fjoms.2000.16629"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0528.1987.tb00480.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177%2F154411130201300503"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00405-007-0346-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tripleo.2004.06.076"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biocel.2006.03.021"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820011001%2992%3A7%3C1888%3A%3AAID-CNCR1706%3E3.0.CO%3B2-Z"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3835%2803%2900382-3"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00428-002-0616-y"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mlg.0000233778.41927.c7"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2004.06053.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/137672","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/137672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:46:14Z","timestamp":1745459174000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000137672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000137672","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}