{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:56:32Z","timestamp":1777946192530,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>Effects on blood pressure and heart rate of prostaglandin (PG) F&lt;sub&gt;2\u03b1&lt;\/sub&gt; administered into a lateral cerebral ventricle (i.e.v.) were investigated in urethane anesthetized rats. PG F&lt;sub&gt;2\u03b1 &lt;\/sub&gt;at doses ranging from 2.4 to 47.4 \u03bcg caused dose-dependent pressor and positive chronotropic actions, but did not exert such actions at a dose of 47.4 \u03bcg in spinal rats. The cardiovascular actions of PG F&lt;sub&gt;2\u03b1&lt;\/sub&gt; were reduced by intravenous (i.v.) pretreatment with hexamethonium (2 mg\/kg). In addition, the pressor action was blocked by phentolamine (5 mg\/kg i.v.) and the positive chronotropic action by propranolol (0.2 mg\/kg i.v.). PG F&lt;sub&gt;2\u03b1&lt;\/sub&gt; (47.4 \u03bcg) and norepinephrine (2 \u03bcg\/kg) injected i.v. induced transient pressor and positive chronotropic actions. This pressor action of norepinephrine was almost completely eliminated but that of PG F&lt;sub&gt;2\u03b1 &lt;\/sub&gt;was only partially inhibited by phentolamine (5 mg\/kg i.v.), while the positive chronotropic actions were unaffected. The results suggest that PG F&lt;sub&gt;2\u03b1&lt;\/sub&gt; accelerates the cardiovascular functions by stimulating the peripheral sympathetic tone through its central action.<\/jats:p>","DOI":"10.1159\/000137826","type":"journal-article","created":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T03:36:29Z","timestamp":1212636989000},"page":"23-28","source":"Crossref","is-referenced-by-count":7,"title":["Central Effects of Prostaglandin F\n                    <sub>2\u03b1<\/sub>\n                    on the Cardiovascular System in the Rat"],"prefix":"10.1159","author":[{"given":"Nobufumi","family":"Ono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,4]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000137826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:47:35Z","timestamp":1777736855000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000137826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000137826","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,4]]}}}