{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:56:50Z","timestamp":1777946210810,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>Although propranolol antagonized CaCl&lt;sub&gt;2&lt;\/sub&gt;-induced arrhythmias in the rat due to its local anaesthetic properties, arrhythmias-protected animals died because of respiratory failure. To assess the relative role played by \u03b22-adrenoreceptor blocking and local anaesthetic properties in the genesis of this phenomenon, five \u03b2-blockers with different degrees of local anaesthetic properties have been tested at their respective ED&lt;sub&gt;50&lt;\/sub&gt; against CaCl&lt;sub&gt;2&lt;\/sub&gt;-induced arrhythmias in the rat and their respective surviving\/arrhythmias-protected animals ratio (SAPAR) calculated.<\/jats:p>","DOI":"10.1159\/000137841","type":"journal-article","created":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T03:36:29Z","timestamp":1212636989000},"page":"103-109","source":"Crossref","is-referenced-by-count":1,"title":["Beta-Adrenoreceptor Blockers and CaCI\n                    <sub>2<\/sub>\n                    -Induced Arrhythmias in the Rat: Discrepancies between Antiarrhythmic Properties and Survival Rate"],"prefix":"10.1159","author":[{"given":"Stefano","family":"Evangelista","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Alberto","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Manzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Meli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,4]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000137841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:47:40Z","timestamp":1777736860000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000137841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000137841","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,4]]}}}