{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:56:53Z","timestamp":1777946213324,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>The effect of 16, 16-dimethyl prostaglandin E&lt;sub&gt;2&lt;\/sub&gt; (DmPGE&lt;sub&gt;2&lt;\/sub&gt;), in doses subthreshold for antisecretory activity, were examined in female rats. The aims were to determine if DmPGE&lt;sub&gt;2&lt;\/sub&gt; alters the disposition of acetylsalicylic acid (ASA) within the gastric mucosa and if DmPGE&lt;sub&gt;2&lt;\/sub&gt; could attenuate the ulcerogenic effect of oral ASA. Gastric lesions occurred after an oral, but not an intravenous dose of 150 mg\/kg ASA. Lesions could be prevented by pretreatment with 5 \u03bcg\/kg DmPGE&lt;sub&gt;2&lt;\/sub&gt; orally 30 min prior to ASA. DmPGE&lt;sub&gt;2&lt;\/sub&gt; elevated fundic concentrations of both ASA and salicylic acid (SA) within the first hour when ASA was given orally. The ratio of the concentration of ASA\/SA in fundus was not changed, indicating that DmPGE&lt;sub&gt;2 &lt;\/sub&gt;did not depress the fundic esterase activity. It is concluded that the cytoprotective effect of DmPGE&lt;sub&gt;2&lt;\/sub&gt; is not related to a change in mucosal concentration or elimination of ASA or SA.<\/jats:p>","DOI":"10.1159\/000137974","type":"journal-article","created":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T03:36:29Z","timestamp":1212636989000},"page":"275-280","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Oral 16,16-Dimethyl Prostaglandin E\n                    <sub>2<\/sub>\n                    on Gastric Mucosal Salicylate Concentration in the Rat"],"prefix":"10.1159","author":[{"given":"U.","family":"Weissenborn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Maedge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.-Fr.","family":"Sewing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,4]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000137974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:48:53Z","timestamp":1777736933000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000137974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000137974","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,4]]}}}