{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:55:53Z","timestamp":1777946153792,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>Single biopsies of human gastric mucosa from controls and different groups of patients were used for enzymatic cell isolation by pronase and collagenase and subsequent count of parietal and nonparietal cells. This procedure was tested in regard to its validity and delivered the following cell numbers. Total gastric cells\/mg wet weight gastric mucosa: normal gastric mucosa [controls (C), n = 95] 31,500 \u00b1 (SEM) 1,490, chronic superficial gastritis (GI; n = 49) 36,300 \u00b1 2,770, chronic gastritis with beginning atrophy (GII; n = 36) 44,100 \u00b1 3,050 (p &lt; 0.025), chronic atrophic gastritis (GUI; n = 12) 40,100 \u00b1 5,760, duodenal ulcer (DU; n = 26) 29,340 \u00b1 2,280, gastric ulcer (GU; n = 23) 37,090 \u00b1 3,000, gastric resection according to Billroth II(BII;n = 7)57,480 \u00b1 12,360 (p &lt; 0.005) and Billroth II (BII; n = 12)52,560 \u00b1 6,730 (p &lt; 0.005). Parietal cells\/mg wet weight gastric mucosa: 1,910 \u00b1 490 (C), 1,980 \u00b1 140 (GI), 1,700 \u00b1 200 (GII), 1,170 \u00b1 220 (GUI, p &lt; 0.025), 2,580 \u00b1 240 (DU, p &lt; 0.05), 1,690 \u00b1 150 (GU), 1,500 \u00b1 250 (BI), 1,360 \u00b1 320 (BII). Parietal cell concentration (density) did not differ in males and females and did not change with age. The method delivers relevant cell numbers, is suitable to detect qualitative differences and can be used for the interpretation of biochemical studies.<\/jats:p>","DOI":"10.1159\/000138209","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T05:40:33Z","timestamp":1212730833000},"page":"121-130","source":"Crossref","is-referenced-by-count":3,"title":["Morphologically Different Biopsy Specimens of the Human Gastric Mucosa"],"prefix":"10.1159","author":[{"given":"H.-J.","family":"Ruoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Leyhe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.B.","family":"Eichhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.-M.","family":"Haile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Malchow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,4]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000138209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:51:43Z","timestamp":1777737103000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000138209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000138209","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,4]]}}}