{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:55:53Z","timestamp":1777946153833,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>The inhibitory effects of the histamine H&lt;sub&gt;2&lt;\/sub&gt;-receptor antagonists, ranitidine and famotidine on histamine-stimulated gastric acid secretion have been studied in guinea pig isolated, enriched parietal cells using the 14C-aminopyrine accumulation technique. The 14C-aminopyrine accumulation curves in response to histamine were shifted towards the right in a parallel fashion by ranitidine, and in a nonparallel fashion by famotidine. The inhibitory effect of ranitidine, but not that of famotidine, was readily reversed by washing the parietal cells. It is concluded that the histamine H&lt;sub&gt;2&lt;\/sub&gt;-receptors in guinea pig parietal cells are blocked competitively and reversibly by ranitidine, but noncompetitively and partially reversibly by famotidine.<\/jats:p>","DOI":"10.1159\/000138226","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T05:40:33Z","timestamp":1212730833000},"page":"274-278","source":"Crossref","is-referenced-by-count":5,"title":["Interaction of Ranitidine and Famotidine with Guinea Pig-Isolated Parietal Cells"],"prefix":"10.1159","author":[{"given":"K.-F.","family":"Sewing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hannemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,4]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000138226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:51:52Z","timestamp":1777737112000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000138226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000138226","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,4]]}}}