{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:56:10Z","timestamp":1777946170299,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T00:00:00Z","timestamp":1212624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T00:00:00Z","timestamp":1212624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>In a short-circuited mucosa-submucosa preparation of the rat descending colon with preserved Meissner\u2019s plexus mounted as an everted sac rhein transiently increased the potential difference and short-circuit current (I&lt;sub&gt;sc&lt;\/sub&gt;) when administered serosally and mucosally, but serosal application was more effective. Maximal effects were obtained at rhein concentrations of 1.6 \u00d7 10\u20134 and 3 \u00d7 10\u20134 mol\/l. Net chloride absorption was decreased. Indometacin (5 \u00d7 10\u20136 mol\/l) did not inhibit the increase of I&lt;sub&gt;sc&lt;\/sub&gt;, but omission of calcium from the serosal side as well as tetrodoxin (2 \u00d7 10\u20137 mol\/l) decreased it by 50 and 60%. Mechanical removal of Meissner\u2019s plexus partly blocked the effect of rhein, too. It is concluded that rhein stimulates colonic secretion by a direct action on the epithelial cells together with an indirect action via neurohumoral mechanisms.<\/jats:p>","DOI":"10.1159\/000138429","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T05:40:33Z","timestamp":1212730833000},"page":"111-119","source":"Crossref","is-referenced-by-count":10,"title":["Rhein Stimulates Active Chloride Secretion in the Short-Circuited Rat Colonic Mucosa"],"prefix":"10.1159","author":[{"given":"K.J.","family":"Goerg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Wanitschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.H.","family":"Meyer zum B\u00fcschenfelde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,5]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000138429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:53:58Z","timestamp":1777737238000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000138429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000138429","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,5]]}}}