{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:57:09Z","timestamp":1777946229994,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T00:00:00Z","timestamp":1212624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T00:00:00Z","timestamp":1212624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>The affinities of telenzepine, pirenzepine and atropine for muscarinic acetylcholine receptors have been determined by receptor binding studies using brain cortex and heart membranes of calf and rat. The ratios of affinities of telenzepine and pirenzepine for the cortical M&lt;sub&gt;1&lt;\/sub&gt; receptors, cortical \u2018non-M&lt;sub&gt;1&lt;\/sub&gt;\u2019 receptors and cardiac M&lt;sub&gt;2&lt;\/sub&gt; receptors are 50:5:1 and 80:5:i, respectively. The time course of association of telenzepine and pirenzepine with M&lt;sub&gt;1&lt;\/sub&gt; receptors is similar, whereas the half-times for dissociation are 35 and 2.3 min at 37 \u00b0C, respectively. In further experiments this slow dissociation rate of telenzepine is shown to be rate-limiting for the occupation of M&lt;sub&gt;1&lt;\/sub&gt; receptors by other ligands. The prolonged occupation of M&lt;sub&gt;1&lt;\/sub&gt; receptors by telenzepine is discussed as a possible protective mechanism against acetylcholine released from vagal nerve fibers.<\/jats:p>","DOI":"10.1159\/000138504","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T05:40:33Z","timestamp":1212730833000},"page":"32-39","source":"Crossref","is-referenced-by-count":8,"title":["Does the Prolonged Occupancy of M\n                    <sub>1<\/sub>\n                    Receptors by Telenzepine Protect Them against the Action of Vagally Released Acetylcholine?"],"prefix":"10.1159","author":[{"given":"C.","family":"Schudt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Auriga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.J.M.","family":"Birdsall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,5]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000138504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:54:44Z","timestamp":1777737284000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000138504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000138504","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,5]]}}}