{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:57:06Z","timestamp":1777946226318,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T00:00:00Z","timestamp":1212624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T00:00:00Z","timestamp":1212624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>A possible interaction between the opiate and \u03b2-adrenergic systems in controlling body temperature, heart rate and water intake was investigated using adult male Sprague-Dawley rats. Peripheral administration of isoproterenol (8 and 50 \u00b5g\/kg, s.c.) produced significant elevations of heart rate and tail skin and colonic temperatures, respectively. Peripheral pretreatment with naloxone (1 mg\/kg, s.c.) was without effect on these \u03b2-adrenergic responses. Administration of isoproterenol (25 \u00b5g\/kg, s.c.) produced a significant increase in water intake which was abolished by peripheral pretreatment with naloxone (1 mg\/kg, s.c). Previous studies have suggested that the dipsogenic response to isoproterenol is mediated through angiotensin II. In the present study the angiotensin II-induced (200 \u00b5g\/ kg, s.c.) dipsogenic response was abolished by naloxone pretreatment. However, pretreatment with an equimolar dose of naloxone methobromide, an opiate antagonist which does not cross the blood-brain barrier, was ineffective in altering the dipsogenic response produced by peripheral administration of either angiotensin II or isoproterenol. Collectively, the data suggest that opiates do not alter peripheral \u03b2-adrenergic responses and that the blocking effects of naloxone on the isoproterenol-induced drinking response is mediated centrally and may be due to blocking angiotensin II dipsogenesis.<\/jats:p>","DOI":"10.1159\/000138714","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T05:40:33Z","timestamp":1212730833000},"page":"167-176","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Peripheral Administration of Naloxone on \u03b2-Adrenergic Mediated Responses"],"prefix":"10.1159","author":[{"given":"Michael J.","family":"Katovich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"Barney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,5]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000138714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:56:51Z","timestamp":1777737411000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000138714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000138714","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,5]]}}}