{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:29:34Z","timestamp":1777537774004,"version":"3.51.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>The pathogenesis of anorexia nervosa (AN) is still poorly understood. The Diagnostic and Statistical Manual of Mental Disorders (4th edition) classification differentiates 2 AN types: the restricting type (AN-R) and the binge eating\/purging type (AN-BP). We investigated 4 young women suffering from AN (2 with AN-R and 2 with AN-BP). Four women, age matched, with other psychiatric disorders (paranoid schizophrenia, adjustment disorder, mental retardation) served as the reference group. The oligonucleotide microarray method (HG-U133A, Affymetrix) was used to determine the expression profile of 13 genes connected with the orexigenic and anorexigenic system: leptin, leptin receptor-coding gene, hypocretin (orexin) receptor-coding gene, hypocretin (orexin) neuropeptide precursor-coding gene and growth hormone secretagogue receptor. A hierarchical analysis of the results showed that AN-BP and AN-R patients were grouped into different clusters. Also, expression levels of leptin receptor-coding gene showed significant differences between AN-BP and AN-R patients and between AN-R and control subjects. This preliminary study suggests that the microarray technique may contribute to elucidating molecular genetics of the pathogenesis of both types of AN.<\/jats:p>","DOI":"10.1159\/000138913","type":"journal-article","created":{"date-parts":[[2008,6,13]],"date-time":"2008-06-13T08:03:26Z","timestamp":1213344206000},"page":"116-120","source":"Crossref","is-referenced-by-count":7,"title":["Preliminary Study of the Expression of Genes Connected with the Orexigenic and Anorexigenic System Using Microarray Technique in Anorexia Nervosa"],"prefix":"10.1159","volume":"57","author":[{"given":"Malgorzata","family":"Janas-Kozik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Stachowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Mazurek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicja","family":"Zajdel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Wilczok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Krupka-Matuszczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz K.","family":"Rybakowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000090701"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2800%2980949-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.1.322"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.neuro.24.1.429"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2004.038737"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1079%2FBJN2003945"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.160.4.657"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2478%2Fs11658-006-0006-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006%2Fabio.1987.9999"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2105-6-115"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00041444-200412000-00004"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/138913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/138913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:21:12Z","timestamp":1745457672000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000138913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000138913","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}