{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:56:33Z","timestamp":1777946193304,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T00:00:00Z","timestamp":1212710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T00:00:00Z","timestamp":1212710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>The effects of histamine H&lt;sub&gt;3&lt;\/sub&gt; receptor activation [(R)\u03b1-methyl-histamine] and blockade (thioperamide) on rat gastric secretion were determined in vivo and in vitro. (R)\u03b1-Methylhistamine (0.1-5 \u00b5mol\/kg i.p.) did not modify secretory volume and acidity in pylorus-ligated rats; it did not affect basal acid secretion and the secretion stimulated by histamine, pentagastrin and 2-deoxy-.D-glucose in the lumen-perfused stomach of anaesthetized rats, when administered by continuous infusion (0.01-1 \u00b5mol\/kg\/h) or bolus injection (0.05-25 \u00b5mol\/kg). In this preparation, the H&lt;sub&gt;3&lt;\/sub&gt; agonist increased acid secretion at doses of 3-25 \u00b5mol\/kg i.v., the effect being antagonized by famotidine. In the isolated gastric fundus from immature rats both (R)\u03b1-methylhistamine (0.01-10 \u00b5mol\/l) and thioperamide (0.01-1 \u00b5mol\/l) were totally ineffective against both spontaneous and stimulated gastric secretion. These results suggest that histamine H&lt;sub&gt;3&lt;\/sub&gt; receptors are unlikely to have a role in regulating gastric acid secretion in the rat.<\/jats:p>","DOI":"10.1159\/000138918","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T05:40:33Z","timestamp":1212730833000},"page":"190-195","source":"Crossref","is-referenced-by-count":18,"title":["Histamine H\n                    <sub>3<\/sub>\n                    Receptors Are Not Involved in the Regulation of Rat Gastric Secretion"],"prefix":"10.1159","author":[{"given":"Gabriella","family":"Coruzzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maristella","family":"Adami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Bertaccini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,6]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000138918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:58:32Z","timestamp":1777737512000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000138918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000138918","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,6]]}}}