{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:56:45Z","timestamp":1777946205264,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T00:00:00Z","timestamp":1213056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T00:00:00Z","timestamp":1213056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>Contractures evoked by 0.1 mmol\/l acetylcholine (ACh) in bundles from mouse soleus muscles denervated for 3-7 days were partly inhibited for more than 1 h following 2- to 10-min exposure to 10-100 \u00b5mol\/l chlorpromazine (CP). The effect was stronger in sucrose than in Na+ solutions. A prolonged ACh-contracture blockage by diltiazem (20 \u00b5mol\/l) was found only in the sucrose solution. Membrane currents evoked by ACh in the absence of Na+ were blocked by both the drugs, but recovered to more than 60% within 1 min of drug washout. ACh-evoked retention of tracer 45Ca2+ was decreased by more than 90 or 70% when CP or diltiazem, respectively, were applied and washed away 10 min before addition of 45Ca2+ and ACh. The results suggest that the prolonged contracture blockage was not related to the blockage of ionic currents through the ACh-receptor channel but to a drug-induced loss of Ca2+-storing capacity.<\/jats:p>","DOI":"10.1159\/000139410","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T09:30:10Z","timestamp":1213176610000},"page":"11-18","source":"Crossref","is-referenced-by-count":2,"title":["Chlorpromazine and Diltiazem Effects in Muscle: Blockage of Acetylcholine-Evoked Contractures, Membrane Currents and Tracer Calcium Uptake"],"prefix":"10.1159","author":[{"given":"H.","family":"Lorkovi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,6,10]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000139410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:03:38Z","timestamp":1777737818000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000139410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000139410","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,10]]}}}